This might be what put Daffy Duck over the edge.
"Duck Amuck", released in 1953, and directed by Chuck Jones, puts Daffy (Mel Blanc) at the mercy of an artist who keeps messing with the scenery and Daffy himself. We've all seen this at least a dozen times.
2 years later, the same thing would happen to Bugs Bunny in "Rabbit Rampage", also directed by Jones. We'll have that one up another time.